Abstract: “A novel human xenograft model of inflammatory breast cancer“, Dr. Sanford Barsky, et.al.
The step of intravasation or lymphovascular invasion can be a rate-limiting step in the metastatic process. Inflammatory breast carcinoma manifests an exaggerated degree of lymphovascular invasion in situ; hence, a study of its molecular basis might shed light on the general mechanism of lymphovascular invasion exhibited by all metastasizing cancers. To this end, we have established the first human transplantable inflammatory breast carcinoma xenograft (MARY-X) in scid/nude mice.
Abstract: “An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma.” Dr. Sanford Barsky, et.al. “The step of intravasation (lymphovascular invasion), a rate-limiting step in metastasis, is greatly exaggerated in inflammatory breast carcinoma (IBC). Because nearly all human breast carcinoma cell lines grow as solitary nodules in nude/severe combined immunodeficient mice without manifesting lymphovascular invasion, this step has been difficult to study. We captured the essence of the IBC phenotype by establishing a unique human transplantable IBC xenograft, MARY-X, which manifests florid lymphovascular emboli in severe combined immunodeficient/nude mice….These findings indicate that it is the gain and not the loss of the E-cadherin axis that contributes to the IBC phenotype.”
Abstract: “Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer.” Shirakawa, et.al. “We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC.”
Abstract: “Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft.” Shirakawa, et.al. “In the present study, we examined hemodynamics in vasculogenic mimicry (VM) and angiogenesis of inflammatory breast cancer (IBC) xenografts (WIBC-9), having previously reported on the unique histological features and molecular basis of these processes (K. Shirakawa et al., Cancer Res., 61: 445-451, 2001). Histologically, the WIBC-9 xenografts exhibited invasive ductal carcinoma with a hypervascular structure (angiogenesis) in the tumor margin and VM without endothelial cells, central necrosis, or fibrosis in the tumor center.”
Abstract: “Rapid Accumulation and Internalization of Radiolabeled Herceptin in an Inflammatory Breast Cancer Xenograft with Vasculogenic Mimicry Predicted by the Contrast-enhanced Dynamic MRI with the Macromolecular Contrast Agent G6-(1B4M-Gd)(256).” Shirakawa, et.al. “The rapid blood flow and perfusion of macromolecules in the inflammatory breast cancer xenograft (WIBC-9), which exhibits a “vasculogenic mimicry” type of angiogenesis without the participation of endothelial cells and expresses high levels of the HER-2/neu antigen…“
