Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients

Selected inflammatory breast cancer research published in 2020

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Fayanju, O M., et al. Extent of Axillary Surgery in Inflammatory Breast Cancer: a Survival Analysis of 3500 Patients. Breast Cancer Research and Treatment, vol. 180, no. 1, Feb. 2020, pp. 207–217., doi:10.1007/s10549-020-05529-1.

Purpose: Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective systemic therapy, it is unclear whether more limited axillary surgery may be appropriate in some IBC patients. We sought to examine whether extent of axillary LN surgery was associated with overall survival (OS) for IBC.
Conclusions: A majority of IBC patients in our study presented with node-positive disease, and for those presenting with cN2-3 disease, more extensive axillary surgery is potentially associated with improved survival. For cN0 patients, however, more extensive axillary surgery was not associated with a survival benefit, suggesting an opportunity for more personalized care.

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