Selected inflammatory breast cancer research published in 2015
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The abstract below is edited for length. Read the free complete article on PubMed Central.
Siamakpour-Reihani, S., et al. (2015). Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival. International Journal of Hyperthermia, 31(4), 386-95. doi: 10.3109/02656736.2015.
We have previously reported that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion patterns obtained from locally advanced breast cancer (LABC) patients prior to neoadjuvant therapy predicted pathologic clinical response. Genomic analyses were also independently conducted on the same patient population. This retrospective study was performed to test two hypotheses: (1) gene expression profiles are associated with DCE-MRI perfusion patterns, and (2) association between long-term overall survival data and gene expression profiles can lead to the identification of novel predictive biomarkers.
Here we have demonstrated an association between DCE-MRI perfusion patterns and gene expression profiles. In addition we have reported on candidate prognostic biomarkers in IBC patients, with some of the genes being significantly associated with survival in IBC and LABC.