Inflammatory breast cancer: the experience of Baylor University Medical Center at Dallas

Selected inflammatory breast cancer research published in 2011

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An abstract is a brief summary of a research article, thesis, review, conference proceeding, or any in-depth analysis of a particular subject and is often used to help the reader quickly ascertain the paper’s purpose. The abstract can convey the main results and conclusions of a scientific article but the full text article must be consulted for details of the methodology, the full experimental results, and a critical discussion of the interpretations and conclusions.

The abstract below is edited for length. Read the free complete article on PubMed Central.

Goldfarb, J. M., & Pippen, J. E. (2011). Inflammatory breast cancer: the experience of Baylor University Medical Center at Dallas. Baylor University Medical Center Proceedings, 24(2), 86-0.

Women diagnosed with IBC have inferior survival outcomes compared with women with other forms of breast cancer. IBC patients tend to be younger, and IBC tumors are more likely to overexpress HER2 than non-IBC tumors. Hormone receptor negativity also occurs at a higher frequency in IBC tumors. At presentation, most women with IBC have lymph node involvement, and approximately one third have distant sites of disease. Historically, attempts to treat IBC with surgery alone or surgery combined with radiation therapy resulted in median overall survival times of less than 15 months and local recurrence rates as high as 50%.

The treatment of IBC has dramatically improved with the advent of multimodality therapy. Results from a large retrospective study of patients with IBC performed over a 20-year period demonstrated that initial treatment with an anthracycline-based regimen followed by local therapy resulted in 5- and 10-year survival rates of 40% and 33%, respectively. The incorporation of taxanes has also been associated with higher pathologic complete response rates and better survival outcomes

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