Perspectives on inflammatory breast cancer (IBC) research, clinical management and community engagement from the Duke IBC Consortium

Selected inflammatory breast cancer research published in 2019

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An abstract is a brief summary of a research article, thesis, review, conference proceeding, or any in-depth analysis of a particular subject and is often used to help the reader quickly ascertain the paper’s purpose. The abstract can convey the main results and conclusions of a scientific article but the full text article must be consulted for details of the methodology, the full experimental results, and a critical discussion of the interpretations and conclusions.

The abstract below is edited for length. Read the free, complete article on PubMed Central.

Devi, G.R., et al. (2019). Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium. Journal of Cancer, 2019 Jun 4;10(15):3344-3351. doi: 10.7150/jca.31176.

Substantial progress has been made over the past 10-15 years in understanding inflammatory breast cancer (IBC) tumor biology for improved treatments through commitment from international investigators as part of IBC programs in the United States, the International IBC Consortium (IBC-IC), and partnerships with cancer foundations. However, a major unmet challenge lies in the lack of awareness about this breast cancer subtype. IBC presents differently than other types of breast cancer; all tumors are stage III or higher at diagnosis. IBC tumor cells spread rapidly and diffusely within the breast instead of presenting as a clinically apparent mass, which can lead to misdiagnosis and treatment delays. Thus, there is a clear need for further investigations into the mechanisms of aggressive IBC behavior, increased research translation into new treatment regimens for improved patient outcomes, and strengthened community dialogue and engagement to help address the global burden and associated health disparity.

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